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Published on: May 4, 2017
CT-P47/Tocilizumab-anoh: A Tocilizumab Biosimilar
1Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. demail@springer.com.
CT-P47 (AVTOZMA®) is a biosimilar to tocilizumab, an IL-6R inhibitor. Clinical studies show CT-P47 is effective and safe for rheumatoid arthritis patients, offering a comparable alternative to the reference drug.
Area of Science:
- Immunology
- Pharmacology
- Rheumatology
Background:
- Tocilizumab is an established IL-6 receptor inhibitor for inflammatory diseases.
- Biosimilars offer comparable therapeutic options with potential for wider accessibility.
Purpose of the Study:
- To evaluate CT-P47 (AVTOZMA®), a biosimilar of tocilizumab, for its efficacy, safety, and immunogenicity.
- To assess the impact of switching from reference tocilizumab to CT-P47.
Main Methods:
- Physicochemical characterization comparing CT-P47 to reference tocilizumab.
- Pharmacokinetic comparability study in patients with moderate to severe rheumatoid arthritis.
- Clinical efficacy and safety assessment, including immunogenicity and switch analysis.
Main Results:
- CT-P47 demonstrated similar physicochemical properties and pharmacokinetic profiles to reference tocilizumab.
- Equivalent clinical efficacy and comparable safety and immunogenicity were observed in rheumatoid arthritis patients.
- Switching from reference tocilizumab to CT-P47 did not negatively impact safety or efficacy.
Conclusions:
- CT-P47 is a clinically effective and safe biosimilar alternative to reference tocilizumab.
- It provides a comparable therapeutic option for patients with rheumatoid arthritis and other approved indications.
- The study supports the use of CT-P47 in managing inflammatory conditions previously treated with tocilizumab.
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