Application of colonoscopic auxiliary devices in reducing the polyp miss rate: a prospective randomized controlled...

To evaluate the effect of a novel-designed colonoscopic distal attachment on the diagnosis of polyps during colonoscopy.

All consecutive patients who underwent routine colonoscopic examinations at Tongji Hospital endoscopy centers in China were enrolled. Participants were randomly assigned in a 1:1 ratio to the auxiliary devices colonoscopy (Experimental Group) or standard colonoscopy groups (Control Group). Adenoma detection rate (ADR), polyp detection rate (PDR), inspection time, duration of treatment and adverse events were recorded.

A total of 264 patients were randomized into the experimental group (EG, n = 132) and the control group (CG, n = 132). The PDR in the EG was significantly higher than in the CG (p = 0.013), while no significant difference was found in the ADR between the two groups (p = 0.078). Insertion and withdrawal times for colonoscopy were showed no statistically significant difference (p = 0.096 and p = 0.868, respectively). Analysis of polyp detection conditions revealed that the EG had a higher number of polyps detected(p = 0.013), and detected more polyps ≤ 5 mm (p = 0.018), and there was no significant difference in the location distribution of detected polyps between the two groups (p = 0.950). Treatment times were showed statistically significant differences, with the EG having shorter treatment times (p = 0.004).

The use of auxiliary devices in colonoscopy significantly improves the PDR, espicialy no-adnoma or smaller polyp, and reduces treatment times compared to standard colonoscopy.

Chinese Clinical Trial Registry (ChiCTR), ChiCTR2500097582, February 21, 2025. Retrospectively registered.