Related Experiment Video
Updated: Jan 16, 2026
Author Spotlight: Hickman Catheter Use for Long-Term Vascular Access in a Preclinical Swine Model
Published on: March 31, 2023
Complications in Central Venous Access Devices in Paediatric Cancer Care: A Global Cross-Sectional Survey
Sabrina de Souza1,2, Mari D Takashima1,2, Areum Hyun3
1School of Nursing, Midwifery and Social Work, Faculty of Health and Behavioural Sciences, The University of Queensland, St Lucia, Queensland, Australia.
Insights
Global practices for managing central venous access device (CVAD) complications in pediatric cancer care differ significantly between high-income and other-income countries. This highlights a need for tailored guidelines and equitable resource access.
Area of Science:
- Pediatric Oncology
- Infectious Diseases
- Medical Devices
Background:
- Central venous access devices (CVADs) are crucial for pediatric cancer treatment.
- Complications like catheter-associated bloodstream infections (CABSI), thrombosis, and occlusion significantly impact patient outcomes.
- Understanding global management variations is essential for improving care.
Purpose of the Study:
- To compare international practices in identifying and managing CVAD complications in pediatric cancer patients.
- To analyze differences in management strategies between high-income and other-income countries.
Main Methods:
- A cross-sectional international survey was conducted among clinicians managing CVADs in pediatric cancer care.
- Data were collected from 161 respondents across 38 countries between 2022 and 2023.
Main Results:
- Diagnostic methods for CABSI varied, with blood cultures more common in high-income countries.
- Antibiotic initiation for CABSI was more frequent based on non-specific criteria in other-income settings.
- Anticoagulation before line removal for thrombosis and alteplase use for thrombosis/occlusion were more prevalent in high-income countries.
Conclusions:
- Significant disparities exist in CVAD complication management based on country income level.
- Context-adapted guidelines, enhanced training, and equitable access to resources are critical for improving global pediatric cancer care.
Objective:
To examine global practices for identifying and managing central venous access device (CVAD) complications-catheter-associated bloodstream infection (CABSI), thrombosis, and occlusion-in paediatric cancer care, comparing patterns between high- and other-income countries.
Methods:
A cross-sectional international survey was conducted from 2022 to 2023 and analysed 2024 to 2025. Clinicians involved in paediatric CVAD cancer care were recruited through global networks.
Results:
A total of 161 respondents from 38 countries completed the complication section, including 102 (63.4%) from high-income and 59 (36.6%) from other-income countries (lower- and upper-middle income). For CABSI, blood culture was the main diagnostic method (122 [75.8%]; high-income: 87 [85.3%], other-income: 35 [59.3%]). Differential time to positivity was more often reported in other-income settings (33 [55.9%] vs. 35 [34.3%]), who also more frequently initiated antibiotics based on nonspecific or immediate criteria. CABSI treatment varied, with intravenous antibiotics (68 [60.7%]) and catheter removal (47 [42.0%]) most reported. For thrombosis, anticoagulation before line removal was common (88 [54.7%]), and alteplase use was higher in high-income countries (76 [74.5%] vs. 19 [32.2%]). Thrombolytic agents were the most reported treatment for occlusion (103 [64.0%]), especially in high-income countries (77 [75.5%] vs. 26 [44.1%]).
Conclusions:
CVAD complication management varies by country income level, highlighting the need for context-adapted guidelines, training, and equitable access to key resources.
More Related Videos
09:57A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
07:47The Supraclavicular Fossa Ultrasound View for Central Venous Catheter Placement and Catheter Change Over Guidewire
Published on: December 23, 2014
Related Concept Videos
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
01:24Hemodialysis II: Procedure and Complications
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
01:29Endocarditis IV: Nursing Management