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A Green Method for Seized Drug Screening Using a Portable Liquid Chromatograph With UV-LED Detection.
1The George Washington University, Washington DC, USA.
Journal of Separation Science
|September 30, 2025
Summary
Portable liquid chromatography offers on-site, real-time seized drug screening. This greener method, using less solvent, meets Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG) guidelines for classical drugs.
Area of Science:
- Analytical Chemistry
- Forensic Science
Background:
- Portable instruments offer on-site, real-time analysis with reduced resource consumption compared to standard instruments.
- The Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG) provides guidelines for drug analysis.
Purpose of the Study:
- To evaluate the suitability of a portable liquid chromatograph for seized drug screening.
- To determine if the portable instrument alone can meet SWGDRUG requirements.
Main Methods:
- Utilized a portable liquid chromatograph with a dual column system.
- Employed on-column dual UV-LED detection.
- Analyzed 16 drugs from various classes.
Main Results:
- All 16 tested drugs were identified using dual relative retention times and dual UV absorbance ratios.
- Most classical, non-novel psychoactive drugs met SWGDRUG identification criteria.
- The portable system demonstrated potential for field-based analysis.
Conclusions:
- Portable liquid chromatography is a viable option for on-site seized drug screening.
- This approach offers a greener alternative to traditional methods with significantly reduced solvent usage.
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