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Targeting chromatin remodeling complexes to treat uveal melanoma

Jonas A Nilsson1

  • 1Sahlgrenska Center for Cancer Research, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Elife
|September 30, 2025
PubMed

Insights

A new compound targeting the BAF chromatin remodeling complex has shown promise, causing tumor regression in an animal model of uveal melanoma. This discovery offers a potential new avenue for treating this incurable eye cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Uveal melanoma is a rare and aggressive primary eye cancer with limited treatment options.
  • The BAF (BRG1/BRM-associated factor) chromatin remodeling complex plays a critical role in regulating gene expression and is often dysregulated in cancers.
Keywords:
BAFSMARCA4/SMARCA2SOX10cancer biologychromatin remodelingmouseuveal melanoma

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