Prognostic Predictors of Oral Mucosal Melanoma-A Systematic Review and Meta-Analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Oral mucosal melanoma (OMM) survival is poor, with a 5-year rate of 34%. Prognostic factors like tumor size, lymph node metastasis, and location significantly impact outcomes for OMM patients.
Area Of Science
- Oncology
- Surgical Oncology
- Cancer Research
Background
- Oral mucosal melanoma (OMM) is a rare and aggressive cancer.
- Prognostic factors for OMM are not well-defined, necessitating further research.
Purpose Of The Study
- To systematically review and perform a meta-analysis to identify prognostic predictors for OMM.
- To improve understanding of factors influencing survival outcomes in OMM patients.
Main Methods
- Searched PubMed, Web of Science, and Scopus for relevant studies (case reports, series, retrospective observational).
- Extracted data on demographics, tumor characteristics, and survival outcomes.
- Conducted a random-effects model meta-analysis and assessed study quality using Murad criteria and JBI checklist.
Main Results
- Included 16 studies (1151 patients) in the review and 5 studies (942 patients) in the meta-analysis.
- Pooled 5-year survival for OMM was 34%.
- Key poor prognostic factors identified: tumor size >4cm, lymph node metastasis, and non-palatal location. Palatal lesions had better survival (85% at 2 years).
Conclusions
- Tumor size, lymph node involvement, and anatomical site are critical prognostic indicators for OMM.
- Standardized staging systems incorporating tumor burden and histopathologic markers are crucial for accurate OMM prognostication.
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