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Metabolic dysfunction-associated steatotic liver disease and diabetes: Together against the heart

Matheus Henrique Gonçalves de Souza1, Pedro Miguel Mattos Nogueira2,3, Cristiane Alves Villela-Nogueira4

  • 1School of Medicine, Department of Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941617, Brazil.

World Journal of Hepatology
|September 30, 2025
PubMed

Insights

Individuals with type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD) face additive cardiovascular risks. Combining these conditions worsens prognosis, increasing mortality from cardiovascular events.

Area of Science:

  • Cardiology
  • Hepatology
  • Endocrinology

Background:

  • Cardiovascular events are the leading cause of mortality in type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD).
  • Co-occurrence of T2DM and MASLD exacerbates liver disease prognosis, increasing risks for steatohepatitis, progression, and hepatocarcinoma.

Keywords:
Cardiovascular outcomesInterplayLiver outcomesLiver steatosisMeta-analysisMetabolic dysfunctionType 2 diabetes mellitus

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