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Coronary computed tomography angiography vs stress testing for stable angina evaluation: Diagnostic and prognostic
Vinay Gundareddy1, Shivam Singla2, Jupalle Mounika3
1Internal Medicine, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States.
Insights
Coronary computed tomography angiography (CCTA) is more effective than stress testing for diagnosing stable angina, improving risk assessment and reducing unnecessary procedures. This approach enhances patient outcomes and supports broader clinical adoption for coronary artery disease evaluation.
Area of Science:
- Cardiology
- Diagnostic Imaging
- Clinical Trials
Background:
- Stable angina pectoris is a common manifestation of coronary artery disease (CAD).
- Non-invasive diagnostic tools like stress testing (ECG, MPI, stress echocardiography) are traditional first-line strategies.
- Coronary computed tomography angiography (CCTA) is increasingly used for direct visualization of coronary stenoses and plaque burden, but its comparative effectiveness is debated.
Purpose of the Study:
- To compare the diagnostic and prognostic performance of CCTA versus stress testing in patients with suspected or confirmed stable angina.
Main Methods:
- A systematic literature search of RCTs published in English within the last 15 years was conducted.
- Studies included adult patients with stable angina or low-risk chest pain, comparing CCTA against ECG, MPI, or stress echocardiography.
- Data extraction and quality assessment (Cochrane Risk of Bias 2.0) were performed, with narrative synthesis due to heterogeneity.
Main Results:
- Five high-quality RCTs involving 5551 patients were included.
- CCTA demonstrated superior diagnostic accuracy and prognostic capability, effectively predicting major adverse cardiac events.
- CCTA was associated with fewer unnecessary invasive coronary angiographies, better event-free survival, and improved revascularization rates compared to stress testing.
Conclusions:
- CCTA is a diagnostically superior and clinically impactful strategy for initial stable angina evaluation, particularly for intermediate pretest probability of CAD.
- It enhances risk stratification, reduces unnecessary procedures, and may improve long-term outcomes compared to conventional stress testing.
- Findings support broader integration of CCTA into diagnostic pathways for stable angina.
Background:
Stable angina pectoris, a clinical manifestation of coronary artery disease (CAD), is commonly evaluated using non-invasive diagnostic tools. Traditionally, stress testing modalities such as exercise electrocardiography (ECG), myocardial perfusion imaging (MPI), and stress echocardiography have been the first-line strategies. However, coronary computed tomography angiography (CCTA), an anatomic imaging modality, is increasingly used for its ability to directly visualize coronary artery stenoses and plaque burden. Despite growing adoption, the comparative effectiveness of CCTA and stress testing in terms of diagnostic accuracy, prognostic value, and clinical outcomes in stable angina remains an area of active debate.
Aim:
To compare the diagnostic and prognostic performance of CCTA with various forms of stress testing in adult patients presenting with suspected or confirmed stable angina.
Methods:
A comprehensive literature search was performed across PubMed, EMBASE, Scopus, and the Cochrane Central Register of Controlled Trials in accordance with the PRISMA guidelines. Only randomized controlled trials (RCT) published in English within the last 15 years were included. Studies involving adult patients (≥ 18 years) with stable angina or low-risk chest pain were selected. The intervention was CCTA, and the comparators included ECG, MPI, and stress echocardiography. Data were extracted using a standardized process, and study quality was assessed using the Cochrane Risk of Bias 2.0 tool. Due to heterogeneity in outcome measures and modalities, narrative synthesis was employed.
Results:
Five high-quality RCTs encompassing a total of 5551 patients were included. CCTA demonstrated superior diagnostic accuracy and prognostic capability across multiple studies. It was more effective in predicting major adverse cardiac events, including myocardial infarction and cardiac death, and was associated with fewer unnecessary invasive coronary angiographies and better event-free survival. Studies also reported improved revascularization rates in patients evaluated with CCTA, particularly within tiered diagnostic protocols. Stress testing, while useful, showed limitations in sensitivity and downstream clinical decision-making.
Conclusion:
CCTA offers a diagnostically superior and clinically impactful strategy for the initial evaluation of patients with stable angina, especially those with intermediate pretest probability of CAD. Compared to conventional stress testing, it enhances risk stratification, reduces unnecessary procedures, and may improve long-term outcomes. These findings support its broader integration into diagnostic pathways for stable angina.
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