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Rectal large cell neuroendocrine carcinoma
Panagiotis Alexandros Drakos1, Antonia A Prountzopoulou2, Efrossini Totskas3
1Barts and the London School of Medicine and Dentistry - Queen Mary, University of London, Garrod Building, Queen Mary University of London, London E1 2AD, England, United Kingdom.
Oxford Medical Case Reports
|September 30, 2025
Summary
Rectal large cell neuroendocrine carcinoma (LCNEC) is rare and aggressive. Early diagnosis using immunohistochemistry (IHC) is crucial for effective management and improved patient outcomes in this challenging cancer.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Rectal large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive malignancy.
- It presents with a poor prognosis and limited median survival.
- Clinical presentation often overlaps with colorectal adenocarcinoma, complicating diagnosis.

