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Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Nose and Nasal Cavity

The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
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Chronic Obstructive Pulmonary Disease-V: Management

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Sinonasal Sarcomas Management: An International Consensus Statement.

Alessandro Vinciguerra1, Francesca Caspani2, Marco Valentini1

  • 1Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Lariana, Como, Italy.

International Forum of Allergy & Rhinology
|September 30, 2025
PubMed
Summary
This summary is machine-generated.

Sinonasal sarcomas, rare head and neck cancers, require histology-specific treatment. Expert consensus highlights the need for individualized, multidisciplinary management due to diverse subtypes and complex anatomy.

Keywords:
Ewing sarcomaangiosarcomabiphenotypic sinonasal sarcomachondrosarcomaleiomyosarcomamalignant peripheral nerve sheath tumorosteosarcomarhabdomyosarcomasinonasal sarcomassynovial sarcoma

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Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Rare Cancers

Background:

  • Sinonasal sarcomas are rare, comprising <7% of head and neck sarcomas.
  • Histological complexity necessitates specialized, multimodal treatment (surgery, radiation, chemotherapy).
  • This study aimed to establish consensus on sinonasal sarcoma management principles.

Purpose of the Study:

  • To gather international expert opinions on sinonasal sarcoma management.
  • To define common principles for treating these rare malignancies.
  • To address the need for standardized, yet individualized, treatment strategies.

Main Methods:

  • Modified Delphi method involving a seven-step international consensus process.
  • Development of 62 statements on sinonasal sarcoma management.
  • Two-round survey administered to 44 recruited experts across multiple continents.

Main Results:

  • Treatment approaches vary by histology: upfront surgery for biphenotypic, chondro-, leio-, and myofibrosarcomas.
  • Chemotherapy, potentially with radiotherapy, is often preferred for Ewing sarcoma and rhabdomyosarcoma.
  • Management for angiosarcoma, liposarcoma, MPNST, osteosarcoma, and synovial sarcoma is less standardized, requiring case-by-case evaluation.

Conclusions:

  • A histology-driven approach is essential for determining initial treatment for sinonasal sarcomas.
  • Prognosis varies significantly among subtypes despite structured management.
  • Multidisciplinary evaluation in referral centers is critical for managing these complex, diverse rare cancers.