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Draft genome sequence of Bordetella pertussis PS21, a circulating clinical isolate from India
Madhumathi Irulappan1, Dhivya Murugan1, Vishnukumar Ramesh1
1Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Abstract:
We report the draft genome sequence of Bordetella pertussis PS21, a clinical isolate obtained from a culture-positive sample from India. The 3.6 Mb genome harbors classical virulence genes and several notable polymorphisms, including a dual substitution in ptxA (Arg5Trp, Met228Ile), a Lys705Glu mutation in bvgS, a Lys97 frameshift in bapC, and a Gly45Ser substitution in ptxB. These mutations may influence pertussis toxin function and virulence regulation, potentially impacting immune recognition by pertussis vaccines.
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