Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

2.2K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
2.2K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.3K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.3K
Knee Joint01:23

Knee Joint

3.0K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
3.0K
Bones of the Lower Limb: Femur and Patella01:16

Bones of the Lower Limb: Femur and Patella

4.7K
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune cells in cardiac homeostasis and disease.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2026
Same author

Predictive factors for functional outcomes in patients receiving total knee arthroplasty.

Medicine·2026
Same author

Single-cell and spatial transcriptomics identify immune-stromal interactions in cardiac allograft vasculopathy.

Nature cardiovascular research·2026
Same author

Non-Inversion Variants in Sporadic Hemophilia A Rarely Recur.

International journal of molecular sciences·2026
Same author

Pulsed Electromagnetic Field Therapy in People with Knee Osteoarthritis: A Systematic Review and Meta-Analysis.

Medicina (Kaunas, Lithuania)·2026
Same author

Genotype-Specific Postural Control Deficits in Hemophilia A: Insights from Center of Pressure Analysis Beyond Radiographic Arthropathy.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Jan 6, 2026

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

3.4K

Developmental Changes in Haemophilic Knee Joint Morphology: A Geometric Morphometric Study.

Chieh-Yu Lin1, Peng-Ta Liu1,2,3, Ming-Ching Shen4

  • 1Department of Physical Medicine and Rehabilitation, Changhua Christian Hospital, Changhua, Taiwan.

Haemophilia : the Official Journal of the World Federation of Hemophilia
|September 30, 2025
PubMed
Summary

Geometric morphometrics revealed significant age-related knee joint changes in haemophilia patients, with patellar position being a key indicator for monitoring and rehabilitation.

Keywords:
geometric morphometric measurementhaemophilia arthropathyknee jointprocrustes analysisradiography

More Related Videos

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

13.0K
Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

3.4K

Related Experiment Videos

Last Updated: Jan 6, 2026

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

3.4K
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

13.0K
Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

3.4K

Area of Science:

  • Orthopedics
  • Radiology
  • Developmental Biology

Background:

  • Haemophilia significantly impacts joint health throughout life.
  • Developmental morphological changes in haemophilic bones are not well understood.
  • Geometric morphometric measurement (GMM) was used to analyze knee joint morphology in haemophilia.

Purpose of the Study:

  • To investigate age-related morphological variations in the knee joints of haemophilia patients.
  • To identify key morphological markers for monitoring disease progression.
  • To inform the development of targeted rehabilitation strategies.

Main Methods:

  • Retrospective analysis of 210 knee radiographs from 15 male haemophilia patients (ages 8-24).
  • 2D bony landmarks were annotated, and Generalized Procrustes analysis was performed.
  • Principal component analysis, Procrustes ANOVA, and multivariate regression were used to assess shape differences and associations with clinical scores (PS, HJHS).

Main Results:

  • Significant morphological differences (p < 0.001) were observed among age groups.
  • The first five principal components explained 83% of morphological diversity.
  • Medial patellar displacement and joint space reduction were notable alterations, with significant differences between the youngest and oldest age groups.

Conclusions:

  • Significant age-related morphological alterations occur in the knee joints of haemophilia patients.
  • Patellar position is a crucial morphological marker for long-term follow-up.
  • Findings support the development of tailored rehabilitation programs for haemophilia.