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A Review of FUN14 Domain-Containing 1 Involvement in Mitochondrial Biological Processes and Mechanisms Across Various

Hailun He1, Xin Zhang2, Lidan Xiong3,4

  • 1Department of Medical Aesthetics, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.

Cell Biochemistry and Function
|September 30, 2025
PubMed

Insights

FUNDC1 protein regulates mitochondrial health and cellular balance. Its dysfunction links to diseases, but targeting it offers therapeutic potential for mitochondrial disorders.

Area of Science:

  • Mitochondrial biology
  • Cellular homeostasis
  • Molecular mechanisms

Background:

  • FUNDC1 is an outer mitochondrial membrane protein regulating mitochondrial quality control.
  • It acts as a mitophagy receptor, orchestrating hypoxia-induced mitophagy via LC3 interactions.
  • FUNDC1's roles extend to mitochondrial dynamics, MAMs, and metabolic regulation.

Purpose of the Study:

  • To review FUNDC1's molecular mechanisms and multifaceted roles.
  • To highlight its involvement in various diseases.
  • To discuss therapeutic strategies targeting FUNDC1.

Main Methods:

  • Literature review synthesizing current research on FUNDC1.
  • Analysis of FUNDC1's involvement in posttranslational modifications.
  • Examination of FUNDC1's crosstalk with cellular pathways.

Main Results:

  • FUNDC1 plays a dual role: protecting cells by clearing damaged mitochondria and potentiating injury through excessive mitophagy.
  • FUNDC1 dysfunction is linked to cardiovascular diseases, neurodegeneration, cancer, and skin conditions.
  • It modulates oxidative stress, apoptosis, pyroptosis, and inflammation.

Conclusions:

  • FUNDC1 is a key regulator of mitochondrial homeostasis with implications in diverse pathologies.
  • Understanding FUNDC1's complex roles is crucial for developing treatments for mitochondrial disorders.
  • Therapeutic targeting of FUNDC1-dependent pathways shows promise for disease intervention.
Keywords:
FUNDC1MAMsmetabolic diseasesmitochondrial dynamicsmitophagy

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