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Comparative evaluation of 3% plain mepivacaine and 2% lignocaine with 1:100,000 adrenaline in the pediatric

Rachita Arora¹, Sayan Chattopadhyay², Stuti Agarwal¹

¹Department of Pediatric Dentistry, Dr. R. Ahmed Dental College and Hospital, Kolkata, West Bengal, India.

Journal of the Indian Society of Pedodontics and Preventive Dentistry

|September 30, 2025

Abstract

Context:

Effective local anesthesia is essential in pediatric dentistry, especially during procedures like pulpectomy. While lignocaine with adrenaline is widely used, mepivacaine without a vasoconstrictor offers potential benefits in pediatric patients.

Aims:

This study aimed to compare the hemodynamic responses and pain perception associated with 3% mepivacaine (plain) versus 2% lignocaine with 1:100,000 adrenaline in children undergoing pulpectomy.

Settings And Design:

A randomized, double-blind controlled trial was conducted at the Department of Pediatric and Preventive Dentistry of Dr. R. Ahmed Dental College and Hospital, Kolkata, India.

Materials And Methods:

Fifty children aged 6-13 years with symptomatic irreversible pulpitis were randomly assigned to receive either mepivacaine or lignocaine through buccal infiltration. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and intraoperative pain (Wong-Baker FACES Pain Rating Scale) were recorded at four time points (preoperatively, 5-, 15-, and 30-min postadministration).

Statistical Analysis Used:

Comparisons within the group over different time points were performed using Friedman's test, while intergroup comparisons at each time point were assessed using the Mann-Whitney U-test. All analyses were conducted with the significance level set at 5%.

Results:

The mepivacaine group showed significantly lower HR at T1 (P < 0.0001) and reduced postoperative pain scores (P = 0.0046). SBP and DBP changes were less pronounced compared to lignocaine, though not statistically significant.

Conclusions:

Mepivacaine without vasoconstrictor provided effective anesthesia with better hemodynamic stability and pain control, supporting its use as a safe alternative in pediatric endodontics, especially where epinephrine use is undesirable.

Keywords:

Anesthesia blood pressure child dental heart rate lidocaine mepivacaine pain measurement pulpectomy randomized controlled trial

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