Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biological Methods for Microbial Control

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...

Modeling with Differential Equations

Modeling with Differential Equations

Population dynamics can be described mathematically by considering the population size P(t) as a function of time. The rate of change of the population is then represented by the derivative of P(t). A simple assumption is that the rate of growth is proportional to the size of the population itself. This leads to an exponential growth model, where the population increases rapidly without bound. While this is a useful first approximation, it does not reflect realistic long-term...

Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

Drugs administered through various routes can lead to nonlinear elimination, resulting in complex pharmacokinetic behaviors crucial to understanding efficacious drug dosing.
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cognitive and emotional benefits of piano training: effects on working memory and psychological well-being.

The Journal of general psychology·2026

Same author

Artesunate repurposing for cytomegalovirus management: a systematic review of efficacy, mechanisms, and perspectives.

Frontiers in cellular and infection microbiology·2026

Same author

Association of testosterone and sex hormone-binding globulin with fat distribution in men: a quantitative water-fat MRI study.

Quantitative imaging in medicine and surgery·2026

Same author

Improving genomic prediction accuracy of complex traits by integrating massive types of functional annotation information.

Nature communications·2026

Same author

Antibiofilm efficacy of phage W5 against antimicrobial-resistant <i>Salmonella</i> Typhimurium targeting biofilms in dairy/meat/egg and on food-processing surfaces (PP/PE).

Applied and environmental microbiology·2026

Same author

Systematic evaluation of phage cocktail-ciprofloxacin combination therapy against multidrug-resistant <i>Salmonella</i> Typhimurium induced gut dysbiosis.

Microbiology spectrum·2026

Search research articles

Related Experiment Video

Updated: Jan 16, 2026

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus

Published on: March 28, 2025

Optimization of echinococcosis control measures based on system dynamics.

Jinrui Ma¹, Xingyu Liu², Zengwen He¹

¹Department of Veterinary Public Health, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.

Plos Computational Biology

|September 30, 2025

Summary

Optimizing echinococcosis control in Gansu Province requires enhanced health education and vaccination coverage. These strategies, utilizing a System Dynamics (SD) model, can significantly reduce human cases and infected sheep by 2026-2027.

More Related Videos

Transient Transduction of the Strobilated Forms of Echinococcus granulosus

Transient Transduction of the Strobilated Forms of Echinococcus granulosus

Published on: September 16, 2022

Procedure to Evaluate the Efficiency of Flocculants for the Removal of Dispersed Particles from Plant Extracts

Procedure to Evaluate the Efficiency of Flocculants for the Removal of Dispersed Particles from Plant Extracts

Published on: April 9, 2016

Related Experiment Videos

Last Updated: Jan 16, 2026

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus

Published on: March 28, 2025

Transient Transduction of the Strobilated Forms of Echinococcus granulosus

Transient Transduction of the Strobilated Forms of Echinococcus granulosus

Published on: September 16, 2022

Procedure to Evaluate the Efficiency of Flocculants for the Removal of Dispersed Particles from Plant Extracts

Procedure to Evaluate the Efficiency of Flocculants for the Removal of Dispersed Particles from Plant Extracts

Published on: April 9, 2016

Area of Science:

Veterinary Public Health
Epidemiology
Mathematical Modeling

Background:

Echinococcosis poses a significant public health challenge in Gansu Province.
Existing prevention and control measures require optimization for greater efficacy.

Purpose of the Study:

To develop and apply a System Dynamics (SD) model for optimizing echinococcosis prevention and control in Gansu Province.
To identify key parameters influencing disease transmission and human/sheep case numbers.

Main Methods:

Establishment of an echinococcosis transmission System Dynamics (SD) model using Vensim software.
Simulation of various intervention scenarios, including vaccination coverage, deworming, slaughter management, and health education.
Sensitivity analysis to determine the impact of different parameters on disease trends.

Main Results:

Human echinococcosis cases were most sensitive to health education levels, followed by vaccination coverage.
Infected sheep numbers were most sensitive to vaccination coverage, followed by slaughter management.
Simulations indicated that increasing health education by 50% and vaccination by 40% could eliminate human cases by 2026.
Increasing vaccination by 60% and slaughter management by 45% could eliminate infected sheep by 2027.

Conclusions:

The study successfully applied SD modeling to optimize echinococcosis control strategies.
Key interventions for reducing human and sheep infections in Gansu Province have been identified.
The findings provide crucial data-driven recommendations for public health decision-making.