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Fluid Composition Analysis in Segmented Microflows via Refractive Index Measurement with Digital In-Line Holography.

Paul Bresson1, Tamar Kurdadze1, Isaac Rodriguez-Ruiz2

  • 1CEA, DES, ISEC, DMRC, Univ. Montpellier, Marcoule, Bagnols-sur-Cèze 30207, France.

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|September 30, 2025
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Summary
This summary is machine-generated.

Digital In-Line Holography (DIH) measures droplet refractive index in microfluidics for hydrometallurgy. This technique enables in situ analysis of non-absorbing phases, crucial for recycling processes.

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Area of Science:

  • Optical Metrology
  • Microfluidics
  • Hydrometallurgy

Background:

  • Conventional UV-vis spectroscopy is ineffective for analyzing non-absorbing phases in liquid-liquid extraction.
  • Accurate in situ measurement of droplet properties is critical for optimizing hydrometallurgical recycling processes.
  • Existing methods lack the capability for real-time, non-invasive analysis of transparent droplets in multiphase systems.

Purpose of the Study:

  • To introduce and validate a novel application of Digital In-Line Holography (DIH) for quantitative in situ refractive index measurement of transparent droplets.
  • To address the analytical gap in hydrometallurgical liquid-liquid extraction systems.
  • To enable simultaneous determination of droplet size and refractive index in segmented microfluidic flows.

Main Methods:

  • Development of a custom microfluidic device for generating monodisperse droplets.
  • Implementation of a DIH optical setup to capture droplet diffraction patterns.
  • Combined image analysis and Lorenz-Mie theory for simultaneous size and refractive index determination.

Main Results:

  • Achieved simultaneous determination of droplet size and refractive index with a precision of Δn ∼ 10⁻².
  • Demonstrated excellent agreement with benchtop refractometry, validating the DIH method.
  • Showcased suitability for monitoring two-phase process variables like acidity in both dispersed and continuous phases.

Conclusions:

  • DIH provides a viable method for quantitative in situ refractive index measurement of transparent droplets in microfluidics.
  • The technique is applicable to monitoring critical process variables in hydrometallurgical liquid-liquid extraction.
  • The approach shows potential for extension to absorbing media and complex multiphase systems, including nuclear fuel reprocessing and critical metal recycling.