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Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice

Bowen Yan1,2, Qingchen Yuan1, Marco M Buttigieg3

  • 1University of Florida College of Medicine, Gainesville, Florida, USA.

The Journal of Clinical Investigation
|September 30, 2025
PubMed

Abstract:

#ClonalHematopoiesis, an #aging related condition caused by mutations in the #blood system, promotes #obesity, and with high-fat #diet drives the risk of #diabetes and #MASLD.

Keywords:
DiabetesHematologyInflammationMetabolismMouse modelsObesity

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