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Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
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Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice
Bowen Yan1,2, Qingchen Yuan1, Marco M Buttigieg3
1University of Florida College of Medicine, Gainesville, Florida, USA.
The Journal of Clinical Investigation
|September 30, 2025
Abstract
None:
#ClonalHematopoiesis, an #aging related condition caused by mutations in the #blood system, promotes #obesity, and with high-fat #diet drives the risk of #diabetes and #MASLD.

