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Updated: Jan 16, 2026

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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Polyphyllin I induces pyroptosis in diffuse large B-cell lymphoma by activating the caspase-6/ZBP1/NLRP3 signaling

Yulian Liu1, Mengyue Fan2, Yuanxin Chen2

  • 1Central laboratory, Linyi People's hospital, Linyi 276000, China; Key Laboratory for Translational Oncology, Xuzhou Medical University, Linyi, 276000, China; Postgraduate Training Base of Linyi People's Hospital, Guangzhou University of Chinese Medicine, Linyi, China; Department of Hematology, Linyi People's Hospital, Linyi, 276000, China; Linyi Key Laboratory of Tumor Biology, Linyi, 276000, China.

International Immunopharmacology
|September 30, 2025
PubMed

Keywords:
Caspase-6/ZBP1/NLRP3 signaling pathwayDiffuse large B-cell lymphomaPolyphyllin IPyroptosis

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