Related Experiment Video
Updated: Jan 16, 2026
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
Published on: June 4, 2020
Use of the NIH Toolbox Cognition Battery in patients with drug-resistant epilepsy: A comparison with
Matthew J Kreinbrink1, Leila Gachechiladze1, Amir Srour1
1Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Abstract:
Cognitive function is an important consideration in treatment planning for patients with drug-resistant epilepsy (DRE). While comprehensive neuropsychological assessments are the gold standard for evaluating cognitive functioning, they are time and resource intensive, often restricting the scope of their use. The NIH Toolbox Cognition Battery (NIHTB-CB) offers a brief, standardized alternative, but its utility in adults with DRE remains unexplored. This study examined the criterion validity of the NIHTB-CB by comparing domain-specific scores to those from gold standard neuropsychological tests in thirty adults with DRE. Strong correlations were found for language (r = 0.83, p < 0.0001) and episodic memory (r = 0.63, p = 0.0003), while other domains showed moderate but non-significant associations. These results suggest that NIHTB-CB tests, particularly those that assess language and episodic memory, may serve as an adjunct tool to monitor and track cognitive function in DRE patients over time.
More Related Videos
07:18A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice
Published on: March 2, 2019
07:02A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019