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The Unique Roles of Adipose Tissue in Wound Healing
Jennifer B Parker1,2, Michelle Griffin1, Deena Akras1
1Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, California, USA.
Advances in Wound Care
|September 30, 2025
Summary
White adipose tissue (WAT) actively regulates wound healing and fibrosis, not just metabolism. Understanding adipocyte roles in repair offers new therapeutic strategies for fibrotic conditions.
Area of Science:
- Adipose tissue biology
- Wound healing and fibrosis research
Background:
- White adipose tissue (WAT) is recognized for energy storage and thermal insulation.
- Beyond metabolism, WAT plays critical roles in dermal and subcutaneous wound healing and scarring.
Purpose of the Study:
- To review the roles of WAT and white adipocytes in wound healing stages: inflammation, proliferation, and remodeling.
- To discuss therapeutic applications of WAT and its derivatives for enhanced wound healing.
Main Methods:
- Literature review focusing on adipocyte involvement in wound repair.
- Analysis of signaling pathways and cellular interactions in wound healing.
Main Results:
- Dermal and subcutaneous WAT are proposed as active regulators, not passive bystanders, in wound healing and fibrosis.
- Adipocytes' specific roles across different wound healing phases are highlighted.
Conclusions:
- Understanding adipocyte subpopulations and WAT in repair and fibrotic processes is crucial.
- Modulating cellular responses involving WAT may lead to future therapeutic applications for fibrotic conditions.
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