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Related Concept Videos

  1. Home
  3. Research Domains
  5. Physical Sciences
  7. Condensed Matter Physics
  9. Surface Properties Of Condensed Matter
  11. A Ph-responsive Nanocarrier Of Peanut Shell Carbon Quantum Dots As A Promising Delivery Of Doxorubicin For Cancer Therapy.
  1. Home
  3. Research Domains
  5. Physical Sciences
  7. Condensed Matter Physics
  9. Surface Properties Of Condensed Matter
  11. A Ph-responsive Nanocarrier Of Peanut Shell Carbon Quantum Dots As A Promising Delivery Of Doxorubicin For Cancer Therapy.

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A pH-responsive nanocarrier of peanut shell carbon quantum dots as a promising delivery of doxorubicin for cancer therapy.

Kaviyapriya Kirubanithy1, Amutha Santhanam2

  • 1Nanobiotherapeutics Laboratory, National Centre for Nanoscience and Nanotechnology, University of Madras, Guindy Campus, Chennai, Tamil Nadu, 600025, India.

Scientific Reports
|September 30, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Peanut shell carbon quantum dots (PS-CQDs) show promise for drug delivery. Functionalized PS-CQDs efficiently delivered doxorubicin to cancer cells, demonstrating potential for targeted cancer therapy.

Keywords:
Cancer therapyCarbon quantum DotsDoxorubicinDrug delivery

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Carbon quantum dots (CQDs) are emerging nanomaterials with significant potential in drug delivery systems due to their unique properties.
  • Surface functionalization of CQDs is crucial for optimizing drug conjugation and controlling release kinetics.
  • Developing biocompatible and efficient drug carriers is essential for advancing cancer therapy.

Purpose of the Study:

  • To synthesize and characterize peanut shell-derived carbon quantum dots (PS-CQDs).
  • To functionalize PS-CQDs and conjugate them with doxorubicin (DOX) for targeted drug delivery.
  • To evaluate the pH-sensitive drug release and in-vitro anticancer efficacy of the DOX-PS-CQDs nanocarrier.

Main Methods:

  • Hydrothermal synthesis of PS-CQDs from peanut shells.
  • Characterization of PS-CQDs' physical and chemical properties, including size, fluorescence, and surface functional groups (hydroxyl, carboxyl, amine).
  • Functionalization of PS-CQDs with hydrazine groups, followed by conjugation with doxorubicin, and assessment of pH-dependent drug release and in-vitro cytotoxicity against MDA MB231 cells.

    • Main Results:

    • PS-CQDs exhibited blue fluorescence, excellent water solubility, and significant free radical scavenging activity (84.7%).
    • The synthesized PS-CQDs had an average size of 2.1 nm and were successfully functionalized and conjugated with doxorubicin (DOX-PS-CQDs).
    • DOX-PS-CQDs demonstrated pH-sensitive doxorubicin release, with higher release at pH 6.5 (81.4%) compared to pH 7.4 (55.4%) over 24 hours, and showed promising in-vitro anticancer activity.

    Conclusions:

    • PS-CQDs are a viable and sustainable source for synthesizing functional nanomaterials for drug delivery.
    • The hydrazine-functionalized PS-CQDs serve as an effective nanocarrier for pH-sensitive and sustained release of doxorubicin.
    • DOX-PS-CQDs exhibit significant potential as a targeted drug delivery system for enhancing cancer therapy efficacy.