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Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
Published on: December 15, 2023
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An optimized hybrid deep learning model to detect Alzheimer disease.
A Sundar Raj1, C Gunasundari2, S Senthilkumar3
1Department of Biomedical Engineering, E.G.S. Pillay Engineering College, Nagapattinam, Tamilnadu, 611002, India. drasr18@gmail.com.
Scientific Reports
|September 30, 2025
Summary
This study introduces an advanced deep learning model for early Alzheimer's disease detection, achieving 96.6% accuracy. The novel approach enhances diagnosis of mild cognitive impairment (MCI) for timely intervention.
Area of Science:
- Neuroscience
- Artificial Intelligence
- Medical Imaging
Background:
- Alzheimer's disease (AD) diagnosis requires early detection for effective treatment, but traditional methods struggle with identifying early stages like mild cognitive impairment (MCI).
- Limitations in feature extraction and classification hinder accurate early-stage AD detection.
Purpose of the Study:
- To develop and evaluate an optimized hybrid deep learning model for improved Alzheimer's disease detection.
- To enhance the accuracy and performance of early AD detection, particularly for MCI stages.
Main Methods:
- A hybrid deep learning model combining Inception v3 for feature extraction and ResNet 50 for classification was developed.
- Network parameters were optimized using the Adaptive Rider Optimization (ARO) algorithm.
- The model was evaluated on a benchmark dementia dataset.
Main Results:
- The proposed model achieved a high accuracy of 96.6%.
- The model demonstrated excellent performance with a precision of 98%, recall of 97%, and F1-score of 98%.
- Results surpassed those of existing state-of-the-art techniques.
Conclusions:
- The optimized hybrid deep learning model shows significant potential for accurate and early Alzheimer's disease detection.
- This approach offers a promising tool for improving the diagnosis of mild cognitive impairment (MCI).
- The model's superior performance suggests a valuable advancement in neurodegenerative disease diagnostics.

