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Updated: Jan 16, 2026

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Published on: August 15, 2018

Transgenic Mouse Models to Study Enteric Glia.

Wilmarie Morales-Soto¹

¹Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. morales-soto.wilmarie@mayo.edu.

Methods in Molecular Biology (Clifton, N.J.)

|October 1, 2025

Summary

This summary is machine-generated.

Research into enteric glia has surged, leading to new tools for studying these cells. This chapter reviews two key transgenic animal models and provides experimental methods for their use in glia research.

Keywords:

DREADs Enteric glia Inducible Cre recombinase Tamoxifen hM3Dq

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Last Updated: Jan 16, 2026

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

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Published on: August 15, 2018

Immunostaining to Visualize Murine Enteric Nervous System Development

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An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse

An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse

Published on: August 7, 2013

Area of Science:

Gastroenterology
Neuroscience
Cell Biology

Background:

Enteric glia play a crucial role in gastrointestinal function and pathophysiology.
Recent research has significantly advanced our understanding of enteric glia biology.
Novel technologies and approaches are emerging for studying enteric glia.

Purpose of the Study:

To review two commonly used transgenic animal models in enteric glia research.
To provide detailed experimental methods for implementing these models.
To facilitate further research into enteric glia mechanisms and their role in gastrointestinal health.

Main Methods:

Review of existing literature on transgenic animal models for glia research.
Detailed description of experimental protocols for two specific transgenic models.
In vivo and ex vivo manipulation techniques for enteric glia.

Main Results:

Identification and description of two key transgenic animal models.
Comprehensive experimental methodologies for utilizing these models.
Foundation for further investigation into enteric glia functions.

Conclusions:

Transgenic animal models are essential tools for advancing enteric glia research.
Standardized methods are crucial for reproducible and effective experimental outcomes.
Continued development of such models will enhance understanding of gastrointestinal regulation and disease.