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Two-sample Mendelian randomization investigating the causal association between endocarditis and osteomyelitis: A
1Department of Orthopedics, The 960th Hospital of PLA, Shandong Second Medical University, Jinan, Shandong, China.
Medicine
|October 1, 2025
Summary
Infective endocarditis (IE) and osteomyelitis (OM) frequently co-occur, but genetic analyses show no direct causal link between these infections. Further research into bacteremia
Area of Science:
- Cardiovascular Medicine
- Infectious Diseases
- Orthopedic Surgery
Background:
- Infective endocarditis (IE) and osteomyelitis (OM) are serious infections that can occur concurrently.
- Understanding the relationship between IE and OM is crucial for effective patient management.
Purpose of the Study:
- To investigate the causal relationship between infective endocarditis (IE) and osteomyelitis (OM).
- To evaluate the co-occurrence rates and explore potential causal links using genetic data.
Main Methods:
- Systematic literature search of major databases (PubMed, Cochrane, Web of Science, Embase).
- Meta-analysis to determine co-occurrence rates of IE and OM.
- Two-sample Mendelian randomization (MR) and multivariable MR analyses using UK Biobank and FinnGen GWAS data.
Main Results:
- Meta-analysis indicated 14% of OM patients had concurrent IE, and 6% of IE patients had comorbid OM.
- Mendelian randomization analyses revealed no significant causal association between IE and OM in either direction.
- Odds ratios for IE causing OM and OM causing IE were 1.01 and 0.87, respectively, with non-significant confidence intervals.
Conclusions:
- While IE and OM frequently co-occur clinically, genetic evidence does not support a direct causal relationship.
- The observed association may be influenced by shared risk factors or mediating mechanisms like bacteremia.
- Further investigation into the role of bacteremia is warranted to elucidate the connection between IE and OM.
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