Case report : pyridaben poisoning induced acute respiratory and circulating failure

Pyridaben, a commonly employed pyridazinone insecticide, is extensively utilized in safeguarding crops against insects and mites. Pyridaben is known to impede mitochondrial complex I activity, inducing mitochondrial impairment, which subsequently culminates in cellular hypoxia, cessation of glycolysis, swift lactic acid buildup, and the onset of lactic acidosis. Prolonged exposure to pyridaben has been demonstrated to elicit deleterious effects on neuronal cells. Furthermore, pyridaben has been associated with the manifestation of cardiotoxicity, leading to abnormal cardiac function.

A 55-year-old Male was expeditiously transported to our medical facility thirty minutes subsequent to ingesting 10 mL of pyridaben. Upon admission, the patient exhibited symptoms of vomiting and coma. Within the next half-hour, he progressed to hypotonic hypoxemia and hypotension as a result of pyridaben intoxication. With the implementation of prompt gastric lavage, oral administration of activated charcoal, respiratory and circulatory support, as well as continuous renal replacement therapy (CRRT), the patient was ultimately discharged successfully without any lingering sequelae.

This case report delineates a rare occurrence of acute human poisoning stemming from contact with novel synthetic pesticides. The document elucidates the clinical manifestations observed and the efficacious administration of supportive therapeutic interventions.