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Clinical and hemodynamic outcomes of hemoperfusion therapy for COVID-19 patients: a historical cohort study

Leila Azizkhani1, Mohammad Ali Yadgary2, Soheila Rabie Siahkali3

  • 1MSc of Nursing, Department of Nursing, School of Nursing and Midwifery, Zanjan University of Medical Sciences, Zanjan, Iran.

BMC Research Notes
|October 1, 2025
PubMed

Insights

Hemoperfusion may improve clinical and hemodynamic status in severe COVID-19 patients. Further research is needed to confirm these findings for COVID-19 treatment.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Cardiovascular Medicine

Background:

  • Inflammation significantly worsens COVID-19 outcomes.
  • Hemoperfusion is a technique to remove circulatory toxins and inflammatory mediators.
  • The efficacy of hemoperfusion in managing COVID-19 remains unclear.

Purpose of the Study:

  • To investigate the clinical and hemodynamic effects of hemoperfusion in COVID-19 patients.
  • To assess the impact of hemoperfusion on patient outcomes and physiological parameters.

Main Methods:

  • A historical cohort study involving 320 COVID-19 patients in Zanjan, Iran (March 2020-June 2022).
  • Data extracted from hospital records using a checklist.
  • Statistical analysis included chi-square, Fisher's exact, Mann-Whitney tests, and repeated measure ANOVA using SPSS v.26.

Main Results:

  • Hemoperfusion showed a statistically significant association with improved clinical status, reduced lung involvement, and lower intubation rates (P<0.05).
  • Significant differences were observed between groups in Glasgow Coma Scale (GCS), platelet count, white blood cell (WBC) count, hemoglobin, respiratory rate, systolic blood pressure, neutrophil and lymphocyte counts, and oxygen saturation (SpO2) over time (P<0.05).

Conclusions:

  • Hemoperfusion may lead to improvements in clinical and hemodynamic status for severe COVID-19 patients.
  • Additional research is recommended to validate these preliminary findings and establish hemoperfusion's role in COVID-19 management.
Abstract

Keywords:
COVID-19HemodynamicsHemoperfusionHospitalization

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