Related Experiment Video
Updated: Jan 16, 2026
07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
1.0K
Matricellular Proteins (MCPs) in Rheumatoid Arthritis
Asiya Kurmanova1, Dieter Riethmacher1
1Department of Biomedical Sciences, School of Medicine, Nazarbayev University, 01000, Astana, Kazakhstan.
Current Medicinal Chemistry
|October 1, 2025
Summary
Matricellular proteins are implicated in rheumatoid arthritis (RA) pathogenesis, influencing inflammation and disease progression. Further research into these proteins may reveal new diagnostic and therapeutic strategies for RA.
Area of Science:
- Immunology
- Biochemistry
- Rheumatology
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease impacting joints and potentially other organs.
- RA affects women twice as often as men, causing significant patient distress and societal costs.
- Disease development involves complex cellular pathways like JAK-STAT, MAPK, PI3K/AKT, and Wnt signaling, leading to cytokine and matrix metalloproteinase production.
Purpose of the Study:
- To review current research on the roles of matricellular proteins in rheumatoid arthritis.
- To explore the potential of matricellular proteins as diagnostic and therapeutic targets for RA.
Main Methods:
- Literature review of published research on matricellular proteins and rheumatoid arthritis.
Main Results:
- Matricellular proteins are involved in extracellular matrix stability and cellular interactions.
- These proteins have demonstrated both pro- and anti-inflammatory roles in RA.
- Matricellular proteins may influence other RA disease propagation processes.
Conclusions:
- Matricellular proteins play a multifaceted role in rheumatoid arthritis.
- Understanding these roles could lead to novel diagnostic markers and therapeutic interventions for RA.
Keywords:
CCN proteinsMatricellular proteinsSPARCTSPsfibulinsosteopontinperiostinrheumatoid arthritistenascins.More Related Videos
Related Concept Videos
01:24T Cell Types and Functions
2.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.2K
01:20The JAK-STAT Signaling Pathway
12.1K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
12.1K
01:23Role of Matrix Metalloproteases in Degradation of ECM
3.3K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
3.3K
01:23Rheumatic Heart Disease I: Introduction
447
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
447
01:26Extracellular Matrix
5.2K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.2K
01:19Mesenchymal Stem Cells
5.5K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.5K