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Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
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Diabetic Neuropathy01:22

Diabetic Neuropathy

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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Related Experiment Video

Updated: May 5, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
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Hydrogel-Based ROS-Regulating Strategy: Reprogramming the Oxidative Stress Imbalance in Advanced Diabetic Wound

Qiaoling Zhou1, Yu Zhuang1, Xiaoling Deng1

  • 1Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Advanced Materials (Deerfield Beach, Fla.)
|October 1, 2025
PubMed
Summary
This summary is machine-generated.

Diabetic wounds struggle to heal due to high oxidative stress. This study explores how engineered hydrogels can intelligently regulate reactive oxygen species (ROS) to improve diabetic wound healing.

Keywords:
ROS scavengingdiabetic woundshydrogeloxidative stress reprogrammingtissue engineering

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Area of Science:

  • Biomaterials Science
  • Wound Healing Research
  • Regenerative Medicine

Background:

  • Diabetic wounds exhibit hyperglycemia and redox imbalance, leading to impaired healing and recurrent ulceration.
  • Excessive reactive oxygen species (ROS) in the wound microenvironment damage cellular components, promote inflammation, and suppress immunity, hindering tissue repair.
  • Current treatments for chronic diabetic wounds face challenges in addressing the complex pathophysiology.

Purpose of the Study:

  • To detail the detrimental role of ROS in diabetic wound progression.
  • To discuss strategies for intelligent ROS regulation using hydrogel platforms for diabetic wound treatment.
  • To outline the therapeutic potential of ROS-regulated hydrogels and identify future research directions.

Main Methods:

  • Reviewing the literature on ROS involvement in diabetic wound pathophysiology.
  • Discussing the design principles and mechanisms of engineered hydrogels for ROS modulation.
  • Analyzing the application of ROS-regulating hydrogels in promoting diabetic wound healing.

Main Results:

  • ROS contribute to oxidative damage, inflammation, immune dysregulation, extracellular matrix degradation, and impaired neovascularization and nerve repair in diabetic wounds.
  • Engineered hydrogels can actively or passively modulate ROS levels in response to external stimuli or the wound microenvironment.
  • ROS-regulated hydrogels demonstrate significant therapeutic potential for accelerating diabetic wound healing.

Conclusions:

  • Intelligent ROS regulation via hydrogels offers a promising therapeutic strategy for overcoming barriers in diabetic wound healing.
  • Further research is needed to address current deficiencies and optimize ROS-regulated hydrogel therapies for clinical application.
  • Future prospects involve developing advanced hydrogel systems for precise, spatiotemporal control of ROS in diabetic wound management.