Pink Urine Syndrome: A Rare Propofol-Associated Phenomenon in Critically Ill Patients

Urine discoloration is a frequent clinical observation that often indicates underlying pathological or pharmacological conditions. Pink urine syndrome (PUS) is a rare phenomenon characterized by the sudden appearance of pink-colored urine, typically attributed to the excretion and crystallization of propofol metabolites. Factors such as obesity, dehydration, and critical illness may exacerbate this condition. Although rare, PUS should be considered in critically ill patients receiving propofol sedation in the intensive care setting. This case report describes the occurrence of PUS in a 29-year-old male with a body mass index of 27.31 kg/m², who was sedated with propofol following an overdose. The urine discoloration resolved after discontinuation of propofol and initiation of hydration therapy, emphasizing the importance of early recognition and prompt intervention. While PUS is benign, generally self-limiting, and resolves without specific treatment, careful monitoring is essential to mitigate potential complications due to precipitation of uric acid crystals, such as urolithiasis, obstructive uropathy, and acute kidney injury, if exposure continues.