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Updated: Jan 16, 2026
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Outcomes of transsphenoidal surgery in 34 small dogs with pituitary-dependent hypercortisolism
Sachiyo Tanaka1, Shuji Suzuki1, Takahiro Teshima1
1Laboratory of Veterinary Surgery (Tanaka, Suzuki, Hara) and Laboratory of Veterinary Internal Medicine (Teshima), Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino-shi, Tokyo 180-8602, Japan; Laboratory of Small Animal Surgery 1, Faculty of Veterinary Science, Kitasato University, 35-1 Higashi 23-bancho, Towada-shi, Aomori 034-0021, Japan (Ishino); Tokyo University of Agriculture and Technology Animal Medical Center, 3-5-8 Saiwai, Fuchu, Tokyo 183-0054, Japan (Kawana); Kasai Rinkai Veterinary Hospital, 6-2-3 Nakakasai, Edogawa-ku, Tokyo 134-0083, Japan (Taoda).
Objective:
This study aimed to evaluate the clinical outcomes of transsphenoidal surgery (TSS) in dogs weighing < 15 kg with pituitary-dependent hypercortisolism (PDH).
Animals:
The study included 34 dogs, each weighing < 15 kg, diagnosed with PDH, and undergoing TSS at our facility between 1999 and 2021.
Procedure:
Postoperative assessments included fatal complications within 4 wk, the extent of mass resection, the duration of central diabetes insipidus, long-term survival, and duration of remission.
Results:
Five dogs died within 4 wk after TSS. Complete resections were completed in 28 dogs, whereas 6 dogs underwent partial resection. Factors associated with partial resection included a higher pituitary-to-brain ratio (odds ratio: 112 705.8; P = 0.014). The median duration of central diabetes insipidus after TSS was 9.5 d. The median long-term postoperative survival was 1228 d. The estimated censored survival rates were 83 and 69% at 1 and 2 y postoperatively, respectively. Recurrence of PDH was observed in 2 dogs, with a median postoperative remission duration of 1188 d. Estimated recurrence-free rates were 90 and 90% at 1 and 2 y postoperatively, respectively.
Conclusion And Clinical Relevance:
Transsphenoidal surgery is an effective treatment for PDH in dogs weighing < 15 kg, particularly when the pituitary gland is small.
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