Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

5.1K
The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
5.1K
Sympathetic Pathways: Sympathetic Chain Ganglia01:20

Sympathetic Pathways: Sympathetic Chain Ganglia

5.7K
The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
5.7K
Nervous Tissue: Neuron Types01:19

Nervous Tissue: Neuron Types

5.9K
Neurons, the fundamental units of the nervous system, can be classified based on both their structural and functional characteristics.
Structurally, neurons are categorized into three main types: multipolar, bipolar, and unipolar (or pseudounipolar). Multipolar neurons, which are the most common type in the brain and spinal cord, as well as all motor neurons, possess multiple dendrites and a single axon.
Bipolar neurons, on the other hand, have one primary dendrite and one axon. They are...
5.9K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.6K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.6K
Spinal Nerves: Plexus I01:22

Spinal Nerves: Plexus I

2.4K
Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
2.4K
Nociception01:44

Nociception

33.0K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
33.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolically and epigenetically reprogrammed splenic TRNP1<sup>hi</sup>CD8<sup>+</sup> T cells exacerbate liver fibrosis.

Nature genetics·2026
Same author

Systemic application of IL-33 for cancer immunoprevention and immunotherapy.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

A Single Flavoenzyme Forges the Pentacyclic Skeleton of α-Cyclopiazonic Acid.

Journal of the American Chemical Society·2026
Same author

Balancing stringency and feasibility: comparative value of disease-activity measures to predict pregnancy outcomes in systemic lupus erythematosus.

Lupus science & medicine·2026
Same author

Lipid-induced granules in hepatocytes alleviate liver fibrosis.

Cell metabolism·2026
Same author

Clusterin Drives Fiber Endocytosis by Mesothelial Cells to Resolve Liver Fibrosis.

Gastroenterology·2025

Related Experiment Video

Updated: Jan 16, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
08:59

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

11.3K

Nerves, nodes, and neoplasia.

Minjun Wang1,2, Censhan Ran3, Quan Liu1,2

  • 1Department of Biochemistry, Southern University of Science and Technology (SUSTech) Homeostatic Medicine Institute, University Laboratory of Metabolism and Health of Guangdong, Shenzhen, Guangdong, China.

Frontiers in Immunology
|October 1, 2025
PubMed
Summary
This summary is machine-generated.

Tumor-draining lymph nodes (tdLNs) are crucial for anti-tumor immunity. This review explores potential tumor-neuro-immune crosstalk within tdLNs, vital for understanding immune evasion and improving cancer therapies.

Keywords:
immunotherapylymph nodenociceptorsympathetic nervetumor immunity

More Related Videos

Establishing In Vitro Models of Dorsal Root Ganglia Culture: Complementary Approaches for Investigating Cancer-Nerve Crosstalk
11:26

Establishing In Vitro Models of Dorsal Root Ganglia Culture: Complementary Approaches for Investigating Cancer-Nerve Crosstalk

Published on: July 11, 2025

1.5K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.5K

Related Experiment Videos

Last Updated: Jan 16, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
08:59

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

11.3K
Establishing In Vitro Models of Dorsal Root Ganglia Culture: Complementary Approaches for Investigating Cancer-Nerve Crosstalk
11:26

Establishing In Vitro Models of Dorsal Root Ganglia Culture: Complementary Approaches for Investigating Cancer-Nerve Crosstalk

Published on: July 11, 2025

1.5K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.5K

Area of Science:

  • Oncoimmunology
  • Neuroimmunology
  • Cancer Biology

Background:

  • Tumor immune evasion and poor immunotherapy response hinder cancer treatment.
  • Tumor-draining lymph nodes (tdLNs) are key sites for anti-tumor immunity and immunotherapy response.
  • Lymph nodes (LNs) are innervated by sensory and sympathetic nerves, suggesting potential neural influence.

Purpose of the Study:

  • To investigate the possibility of tumor-neuro-immune crosstalk within tdLNs.
  • To synthesize emerging evidence supporting neural regulation of immune responses in the tumor microenvironment.
  • To highlight the importance of tdLNs in cancer immunology and therapy.

Main Methods:

  • Review of existing literature on LN anatomy, innervation, and neural regulation of immune cells.
  • Analysis of tumor-neuro-immune interactions, including nerve growth and neural regulation of tumor progression.
  • Synthesis of evidence to propose potential interactions within tdLNs.

Main Results:

  • LNs are innervated, and neural regulation impacts immune activities, particularly in a tumor context.
  • tdLNs play multifaceted roles, including orchestrating immunity, local immunosuppression, and immune tolerance.
  • Tumor-neural interactions involve tumor-induced nerve growth and neural regulation of tumor progression.

Conclusions:

  • Tumor-neuro-immune crosstalk in tdLNs is a plausible and critical area for investigation.
  • Understanding these interactions is essential for overcoming immune evasion and advancing cancer treatment strategies.
  • Further research into tdLN handling in cancer therapy may yield significant clinical implications.