Stomatognathic Diseases Reveal Bidirectional Link Between Diabetes Mellitus and Coronary Artery Calcium: A...

Area of Science:

• Cardiovascular Health
• Metabolic Disorders
• Data Science in Medicine

Background:

• Diabetes mellitus (DM) significantly increases cardiovascular disease (CVD) risk.
• Endothelial dysfunction, inflammation, and metabolic issues link DM to CVD.
• Understanding the DM-CVD relationship is vital for healthcare.

Purpose of the Study:

• To explore the bidirectional relationship between DM and coronary artery calcification (CAC).
• To investigate the mediating role of stomatognathic (oral) diseases in the DM-CAC link.
• To apply advanced data science techniques for novel insights.

Main Methods:

• Utilized a public dataset of 212 patients from Dutch hospitals.
• Employed tensor decomposition to analyze DM and CAC interrelations.
• Integrated patient characteristics and dental data into tensor models.
• Applied k-NN search, fuzzy recurrence plots, and entropy measures.

Main Results:

• Tensor decomposition identified patterns linking patient characteristics and dental conditions across DM and CAC groups.
• k-NN analysis confirmed a bidirectional relationship between DM and CAC.
• Fuzzy recurrence plots and entropy measures distinguished patterns among patient groups.

Conclusions:

• A reciprocal interaction exists between DM and CAC, particularly in higher tertiles.
• Patient characteristics and oral health are crucial for uncovering latent patterns.
• Oral conditions serve as significant indicators in the complex DM-CAC relationship.