Related Experiment Video
Updated: Jan 16, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
Published on: May 16, 2025
Global Trends in the Research of Ulcerative Colitis Treatments (2021-2025): A Bibliometric Review
Jorge Zapatier1, Ethan Nichols2, Vindhya N Reddy3
1Department of Biology, Orlando Science High School, Orlando, USA.
Abstract:
Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease characterized by mucosal ulceration and inflammation confined to the colonic epithelium. While colonoscopy remains the diagnostic gold standard, fecal calprotectin (FC) is a validated non-invasive biomarker. Therapeutic management encompasses immunosuppressive agents including anti-TNF biologics such as infliximab, vedolizumab, and ustekinumab for severe disease manifestations, whereas mild-to-moderate UC is managed with variable dosing regimens of 5-aminosalicylates administered via oral or rectal routes. This bibliometric analysis utilized the Web of Science (WoS) database to extract publication data spanning from January 1, 2021, to June 14, 2025, with subsequent exportation of tab-delimited datasets to VOSviewer (version 1.6.20) for comprehensive bibliometric visualization and analysis. Bibliometric analysis demonstrated that the People's Republic of China exhibited the highest publication output with predominantly recent scholarly contributions. Therapeutic research predominantly focused on biologic agents, specifically infliximab (677 publications), vedolizumab (269 publications), and ustekinumab (234 publications) over the five-year study period. Temporal analysis utilizing the WoS Core Collection revealed consistent publication growth, with 2024 demonstrating peak research output. Categorical distribution analysis indicated "Gastroenterology Hepatology" as the predominant research domain.
More Related Videos
06:24Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
Published on: October 13, 2023
07:38Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
Published on: September 13, 2016
Related Concept Videos
Drugs for Treatment of Ulcerative Colitis in IBD
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents