Effectiveness and use of evidence-based cardiovascular preventive therapies in type 2 diabetes patients with established or high risk of atherosclerotic cardiovascular disease
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View abstract on PubMed
Summary
This summary is machine-generated.Evidence-based cardiovascular therapies significantly lower risks of major adverse cardiovascular events, heart failure hospitalization, and kidney disease in type 2 diabetes patients. Increased medication use was observed, but further strategies are needed for wider implementation.
Area Of Science
- Cardiology
- Endocrinology
- Nephrology
Background
- Type 2 diabetes (T2DM) patients with established or high atherosclerotic cardiovascular disease (ASCVD) risk require effective preventive strategies.
- Evidence-based cardiovascular preventive therapies are crucial for managing cardiovascular and renal outcomes in this population.
Purpose Of The Study
- To investigate the association between evidence-based cardiovascular preventive therapies and cardiovascular/renal outcomes in T2DM patients at high ASCVD risk.
- To assess the impact of these therapies on major adverse cardiovascular events (3-P MACE), heart failure hospitalization (HHF), and kidney disease progression.
Main Methods
- A cohort study utilizing diagnostic codes from Xiamen Humanity Hospital (2018-2023).
- Inclusion of T2DM patients with established or high ASCVD risk (Cohort 1: 5,335 patients, Cohort 2: 17,320 patients).
- Primary outcomes analyzed: 3-P MACE, HHF, and end-stage kidney disease or doubling of serum creatinine.
Main Results
- Use of at least one evidence-based therapy was associated with reduced risk of 3-P MACE (HR, 0.82), HHF (HR, 0.66), and kidney disease (HR, 0.73).
- Significant increases in the uptake of key therapies observed from 2018-2023: GLP-1 RAs (2.7% to 13.7%), SGLT2 inhibitors (3.9% to 16.5%), ACEi/ARBs (28.1% to 43.0%), statins (61.6% to 70.5%), and aspirin (23.7% to 32.9%).
Conclusions
- Evidence-based cardiovascular preventive medications offer significant benefits for T2DM patients with established or high ASCVD risk.
- Despite modest increases in therapy use, barriers to implementation persist, necessitating further strategies to improve adoption.
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