Prognostic impacts of marital status and other socioeconomic factors in patients with chronic lymphocytic leukemia: an analysis of SEER database
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View abstract on PubMed
Summary
This summary is machine-generated.Marital status significantly impacts survival in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Married patients exhibit better outcomes, informing risk stratification and targeted interventions for improved CLL/SLL management.
Area Of Science
- Hematology
- Oncology
- Epidemiology
Background
- Marital status influences outcomes in various cancers.
- The prognostic significance of marital status in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) remains unestablished.
Purpose Of The Study
- To investigate the prognostic role of marital status in overall survival (OS) and disease-specific survival (DSS) for patients with CLL/SLL.
- To develop and validate predictive nomograms incorporating marital status for risk stratification in CLL/SLL.
Main Methods
- Utilized data from 67,238 CLL/SLL patients from the SEER database.
- Employed univariate and multivariate Cox regression analyses to identify survival predictors.
- Developed and validated nomograms using C-index, calibration curves, ROC curves, and decision curve analysis.
Main Results
- Marital status emerged as an independent predictor of OS and DSS.
- Married patients demonstrated superior survival compared to single, divorced, or widowed individuals.
- Nomograms incorporating marital status showed favorable discrimination and predictive accuracy, enabling effective risk group stratification.
Conclusions
- Married marital status is associated with improved survival in CLL/SLL patients.
- Integrating marital status into nomograms offers a practical tool for enhanced risk stratification.
- Identifying widowed patients as high-risk facilitates targeted interventions and surveillance strategies in CLL/SLL care.
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