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Relationship Between Lymphocyte-Associated Inflammatory Markers and Post-Stroke Cognitive Impairment
Qian-Ying Hu1, Juan Liu1, Cai-Hong Cui1
1Department of Rehabilitation Medicine, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, People's Republic of China.
Journal of Inflammation Research
|October 1, 2025
Summary
Ultra-early stroke inflammatory markers like NIHSS show predictive value for cognitive impairment. Neutrophil-to-lymphocyte ratio (NLR) may serve as a screening tool for post-stroke cognitive impairment (PSCI).
Area of Science:
- Neurology
- Immunology
- Biochemistry
Background:
- Post-stroke cognitive impairment (PSCI) is a common complication affecting recovery and quality of life.
- Early identification of risk factors for PSCI is crucial for timely intervention.
Purpose of the Study:
- To investigate the association between ultra-early lymphocyte-related inflammatory markers and PSCI.
- To evaluate the predictive value of these markers for cognitive impairment within 30 days of stroke onset.
Main Methods:
- Retrospective analysis of blood markers and neurological deficit scores (NIHSS) within 24 hours of stroke onset.
- Patients were grouped based on the development of PSCI within 30 days.
- Multivariate analysis was used to assess independent associations.
Main Results:
- The National Institutes of Health Stroke Scale (NIHSS) was independently associated with PSCI (OR=1.297, p<0.001).
- Neutrophil-to-lymphocyte ratio (NLR) showed a borderline association with PSCI (OR=1.107, p=0.063).
- NLR demonstrated high specificity, suggesting its utility in screening for PSCI.
Conclusions:
- NIHSS is a significant predictor of PSCI.
- NLR shows potential as a screening biomarker for PSCI due to its high specificity.
- Further research with larger sample sizes and longer follow-up is recommended for MLR and ULR.
