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Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Atherosclerosis III: Management01:26

Atherosclerosis III: Management

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Longitudinal Research02:20

Longitudinal Research

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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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  11. Association Between High-sensitivity C-reactive Protein And Longitudinal Changes In Arteriosclerosis Over Time: The Kailuan Prospective Cohort Study.
  1. Home
  3. Research Domains
  5. History, Heritage And Archaeology
  7. Historical Studies
  9. European History (excl. British, Classical Greek And Roman)
  11. Association Between High-sensitivity C-reactive Protein And Longitudinal Changes In Arteriosclerosis Over Time: The Kailuan Prospective Cohort Study.

Related Experiment Video

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Association Between High-Sensitivity C-Reactive Protein and Longitudinal Changes in Arteriosclerosis Over Time: The Kailuan Prospective Cohort Study.

Weizhe Li1, Pei Liang2, Zhao Han3

  • 1Department of Emergency Internal Medicine No. I, Handan Central Hospital, Handan, Hebei, 056001, People's Republic of China.

Journal of Inflammation Research
|October 1, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

High-sensitivity C-reactive protein (hs-CRP) levels show a dose-response relationship with arterial stiffness progression over time. This association is more significant in males, highlighting hs-CRP as a predictor of arteriosclerosis.

Keywords:
ankle-brachial pulse wave velocityarteriosclerosishigh-sensitivity C-reactive proteinlinear mixed-effects model

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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Epidemiology

Background:

  • Arteriosclerosis, a hardening of the arteries, is a significant risk factor for cardiovascular disease.
  • High-sensitivity C-reactive protein (hs-CRP) is a marker of systemic inflammation.
  • Understanding the link between inflammation and arterial stiffness is crucial for predicting cardiovascular events.

Purpose of the Study:

  • To investigate the relationship between baseline high-sensitivity C-reactive protein (hs-CRP) levels and the longitudinal progression of arterial stiffness.
  • To determine if there is a dose-response relationship between hs-CRP and changes in arterial stiffness over time.
  • To explore potential differences in this relationship based on gender.

Main Methods:

  • Prospective cohort study involving 25,336 participants from the Kailuan study.
  • Participants were categorized into three groups based on baseline hs-CRP levels (<1 mg/L, 1-3 mg/L, >3 mg/L).
  • Longitudinal changes in brachial-ankle pulse wave velocity (baPWV) were analyzed using linear mixed-effects models.

    • Main Results:

    • Over an average follow-up of 4.62 years, baPWV increased in all groups.
    • A significant dose-response relationship was observed: higher hs-CRP levels were associated with a greater rate of baPWV increase.
    • The association between hs-CRP and baPWV progression was more pronounced in males.

    Conclusions:

    • Elevated hs-CRP levels are significantly associated with the longitudinal progression of arterial stiffness.
    • A clear dose-response relationship exists between hs-CRP and arterial stiffness progression.
    • The pro-atherosclerotic effect of hs-CRP is more pronounced in men, suggesting gender-specific risk stratification.