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Natural Compounds as Potential Therapeutics for Pancreatic Cancer: A Narrative Review
Xing-Da Lin1, Tian Li2, Rui-Xia Du3
1Department of Pancreatic-Biliary Surgery, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Abstract:
Pancreatic cancer is a highly lethal malignancy with a low 5-year survival rate. This review focuses on natural compounds as potential therapeutics for it. Different types of natural compounds, such as polyphenols, saponins, and alkaloids, have shown anti-pancreatic cancer effects, including inhibiting tumor cell growth, inducing apoptosis, and preventing angiogenesis. They also have indirect impacts on pancreatic cancer through influencing the gut microbiota, glucose and lipid metabolism, and the endocrine system. Additionally, Chinese herbal medicines containing these compounds show promise in clinical applications. However, challenges such as target identification and low bioavailability persist. Future research trends involve interdisciplinary collaboration and the use of advanced technologies to overcome these issues.
Insights
Natural compounds like polyphenols show promise in treating pancreatic cancer by inhibiting tumor growth and affecting metabolism. Further research and advanced technologies are needed to overcome challenges like bioavailability.
Area of Science:
- Oncology
- Pharmacology
- Natural Products Chemistry
Background:
- Pancreatic cancer is a deadly disease with poor survival rates.
- Current treatments have limitations, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review natural compounds as potential therapeutics for pancreatic cancer.
- To explore the mechanisms of action and clinical potential of these compounds.
Main Methods:
- Literature review of studies on natural compounds and pancreatic cancer.
- Analysis of preclinical and clinical data on polyphenols, saponins, and alkaloids.
- Examination of indirect effects on gut microbiota, metabolism, and endocrine system.
Main Results:
- Natural compounds exhibit anti-pancreatic cancer activities, including inhibiting cell growth, inducing apoptosis, and preventing angiogenesis.
- These compounds influence pancreatic cancer indirectly via gut microbiota and metabolic pathways.
- Chinese herbal medicines show clinical promise.
Conclusions:
- Natural compounds offer a promising avenue for pancreatic cancer therapy.
- Challenges include target identification and bioavailability, requiring further investigation.
- Interdisciplinary collaboration and advanced technologies are crucial for future development.
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