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Related Concept Videos

Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

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The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
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Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

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A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
253
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

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Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
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Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

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In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs...
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Urinary Tract Calculi V: Nursing Management01:28

Urinary Tract Calculi V: Nursing Management

266
AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
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  1. Home
  3. Research Domains
  5. Law And Legal Studies
  7. International And Comparative Law
  9. Conflict Of Laws (incl. Private International Law)
  11. Triamcinolone Application Following Internal Urethrotomy For Reducing Urethral Stricture Recurrence Rate: A Systematic Review And Meta-analysis Of Randomized Controlled Trials.
  1. Home
  3. Research Domains
  5. Law And Legal Studies
  7. International And Comparative Law
  9. Conflict Of Laws (incl. Private International Law)
  11. Triamcinolone Application Following Internal Urethrotomy For Reducing Urethral Stricture Recurrence Rate: A Systematic Review And Meta-analysis Of Randomized Controlled Trials.

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Vessel-sparing Excision and Primary Anastomosis
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Triamcinolone application following internal urethrotomy for reducing urethral stricture recurrence rate: a systematic review and meta-analysis of randomized controlled trials.

Dimas Panca Andhika1, Tarmono Djojodimedjo1, Furqan Hidayatullah1

  • 1Department of Urology, Faculty of Medicine, Airlangga University, Surabaya.

Archivio Italiano Di Urologia, Andrologia : Organo Ufficiale [Di] Societa Italiana Di Ecografia Urologica E Nefrologica
|October 1, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

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Triamcinolone ointment applied with clean intermittent catheterization (CIC) effectively reduces urethral stricture recurrence after internal urethrotomy. Submucosal injections of triamcinolone did not show this benefit, and neither method impacted urinary flow rate.

Area of Science:

  • Urology
  • Surgical Innovation
  • Pharmacological Adjuncts

Background:

  • Urethral stricture, a narrowing of the urethra due to scar tissue, affects approximately 200 per 100,000 individuals.
  • Internal urethrotomy is a common treatment for short strictures, but high recurrence rates necessitate improved therapeutic strategies.
  • Adjunctive therapies, such as triamcinolone application, are being investigated to enhance treatment outcomes for urethral stricture disease.

Purpose of the Study:

  • To evaluate the efficacy of triamcinolone as an adjunctive therapy to internal urethrotomy in reducing urethral stricture recurrence.
  • To compare the effectiveness of different triamcinolone administration methods (ointment with CIC vs. submucosal injection).

Main Methods:

  • A systematic literature search was performed across major databases (PubMed, ScienceDirect, Google Scholar).
  • The review adhered to PRISMA guidelines, with the protocol registered in PROSPERO (CRD42020202254).
  • Six randomized controlled trials (RCTs) involving 373 patients were included in the meta-analysis.

    • Main Results:

    • Pooled analysis of six RCTs revealed a significantly lower recurrence rate of urethral strictures in the triamcinolone group compared to the control group (OR = 0.49).
    • Triamcinolone ointment combined with clean intermittent catheterization (CIC) demonstrated a significant reduction in recurrence (OR = 0.47, p=0.009).
    • Submucosal triamcinolone injection did not significantly reduce recurrence rates, and maximum urinary flow rate (Qmax) remained similar between groups at 6 and 12 months.

    Conclusions:

    • Triamcinolone ointment administered with CIC is an effective adjunctive treatment for reducing urethral stricture recurrence post-internal urethrotomy.
    • Submucosal triamcinolone injection does not offer significant benefits in preventing recurrence.
    • Neither application method negatively impacts maximum urinary flow rate.