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Microbial phenazines: biosynthesis, structural diversity, evolution, regulation, and biological significance.

Dmitri V Mavrodi1, Wulf Blankenfeldt2, Olga V Mavrodi3

  • 1USDA, Agricultural Research Service, Wheat Health, Genetics and Quality Research Unit, Pullman, Washington, USA.

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|October 1, 2025
PubMed
Summary

Phenazines are bacterial compounds crucial for microbial survival in harsh conditions. Their diverse structures and evolutionary pathways highlight their roles in ecological interactions and potential applications in agriculture and health.

Keywords:
biosynthesisevolutionhorizontal gene transfermicrobial interactionsmode of actionphenazinesphysiologyregulation

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Area of Science:

  • Microbiology
  • Biochemistry
  • Evolutionary Biology

Background:

  • Phenazines are redox-active secondary metabolites produced by bacteria.
  • They facilitate electron transfer, aiding microbial survival in oxygen-limited or stressful environments.

Purpose of the Study:

  • To review the structural diversity and evolutionary history of phenazine biosynthetic pathways.
  • To explore environmental regulation of phenazine production.
  • To examine the ecological roles and potential applications of phenazines.

Main Methods:

  • Literature review of phenazine biosynthesis, evolution, and ecological functions.
  • Analysis of structural diversity and horizontal gene transfer events.
  • Investigation of environmental factors and signaling pathways regulating production.

Main Results:

  • Phenazine structures exhibit extensive diversity.
  • Biosynthetic pathways evolve through horizontal gene transfer between species.
  • Environmental factors and cell-to-cell signaling modulate phenazine production.
  • Phenazines act as antimicrobial agents and shape microbiome dynamics.

Conclusions:

  • Understanding phenazine biology illuminates microbial adaptation strategies.
  • Phenazines have significant potential applications in agriculture and human health.
  • Horizontal gene transfer is a key driver of phenazine pathway evolution.