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Related Experiment Video

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Risk Prediction Models of Cardiotoxicity in Patients With Breast Cancer: Multicenter Prospective CHECK HEART-BC

Yosuke Terui1, Kotaro Nochioka1, Hideki Ota2

  • 1Department of Cardiovascular Medicine, Tohoku University Graduate School of Public Health, Tokyo, Japan.

JACC. Asia
|October 1, 2025
PubMed
Summary
This summary is machine-generated.

A new risk model accurately predicts chemotherapy-induced cardiotoxicity in breast cancer patients. This tool aids early detection and surveillance, improving cardiac event outcomes for patients receiving cancer treatment.

Keywords:
cardio-oncologycardiomyopathychemotherapypredictive model

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Area of Science:

  • Cardiology
  • Oncology
  • Medical Imaging

Background:

  • Early detection and treatment of cardiotoxicity are crucial for reducing cardiac events in cancer patients.
  • A reliable predictive model for chemotherapy-induced cardiotoxicity in breast cancer patients is currently lacking.

Purpose of the Study:

  • To develop a risk prediction model for cardiotoxicity.
  • To establish effective surveillance strategies for cardiotoxicity in breast cancer patients undergoing chemotherapy.

Main Methods:

  • Prospective screening of 559 chemotherapy-naïve female breast cancer patients across 25 institutions.
  • Cardiotoxicity defined as >10% reduction in left ventricular ejection fraction from baseline to <53%.
  • Development of the CHECK HEART score using 6 predictive variables.

Main Results:

  • Cardiotoxicity observed in 8.2% of patients during a median 366-day follow-up.
  • The CHECK HEART score incorporates heart rate, cardiac imaging parameters, and specific chemotherapy agents (anthracycline, trastuzumab).
  • Pretreatment data-based CHECK HEART score demonstrated acceptable predictive accuracy (AUC: 0.82) at 12 months.

Conclusions:

  • Multivariable risk prediction models accurately predict cardiotoxicity in breast cancer patients receiving chemotherapy.
  • The developed models can support effective surveillance and management of cardiotoxicity.