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SkinspanTM: A Healthy Longevity Framework for Skin Aging.

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Skin aging results from intrinsic and extrinsic factors, impacting skin structure and function. Understanding these causes is key to developing new therapies for extending skin healthspan.

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Area of Science:

  • Dermatology and Gerontology
  • Molecular Biology and Genetics

Background:

  • Skin aging is a significant aspect of overall human aging, with increasing prevalence of age-related skin conditions.
  • Both intrinsic (hormonal, genetic, cellular senescence) and extrinsic (UV radiation, pollution, lifestyle) factors contribute to skin aging.
  • The skin's layered structure (epidermis, dermis, hypodermis) undergoes changes due to interconnected aging hallmarks.

Purpose of the Study:

  • To review the multifaceted nature of skin aging, encompassing its biological drivers and consequences.
  • To highlight the impact of the skin exposome on visible and physiological aging processes.
  • To emphasize the need for novel therapeutic strategies to address skin aging and extend skin healthspan.

Main Methods:

  • Comprehensive literature review of intrinsic and extrinsic factors influencing skin aging.
  • Analysis of cellular and molecular mechanisms underlying age-related skin changes.
  • Synthesis of current understanding of hallmarks of aging in the context of skin.

Main Results:

  • Intrinsic factors like cellular senescence and epigenetic alterations impair skin renewal and structure.
  • Extrinsic factors such as UV radiation and pollution exacerbate aging through oxidative stress and DNA damage.
  • Hallmarks of aging, including stem cell exhaustion and inflammaging, accelerate skin aging phenotypes like reduced elasticity and delayed healing.

Conclusions:

  • Skin aging is a complex process driven by the cumulative effects of the skin exposome.
  • Current interventions focus on prevention and management, but emerging therapies targeting root causes show promise.
  • Recognizing, preventing, and treating skin aging are crucial for improving dermatologic care and extending skin healthspan (skinspan).