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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
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Drug repurposing in cancer research: a bibliometric analysis
Uche Samuel Ndidi1, Israel Ogwuche Ogra2,3, Emohchonne Utos Jonathan4
1Department of Biochemistry, Ahmadu Bello University, Zaria, Kaduna State, Nigeria. usndidi@abu.edu.ng.
Discover Oncology
|October 1, 2025
Summary
Drug repurposing for cancer research is rapidly expanding, with the USA and China leading contributions. Key areas include antineoplastic activity, with pantoprazole and transwell assays showing emerging trends.
Area of Science:
- Oncology
- Pharmacology
- Bibliometrics
Background:
- Cancer presents a significant global health challenge.
- Drug repurposing offers an effective strategy for identifying new cancer drug candidates by leveraging existing drugs.
- Bibliometric analysis provides a comprehensive overview of research trends and development in this field.
Purpose of the Study:
- To assess the current state, focal points, and trends in drug repurposing for cancer research.
- To provide a detailed overview of research development and identify future research directions.
- To analyze publication data from 2008-2024 to understand the field's trajectory.
Main Methods:
- Bibliometric analysis of 1166 documents from the Scopus database (2008-2024).
- Utilized Bibliometrix R package and VOSviewer for data analysis.
- Identified leading countries, journals, authors, and research topics.
Main Results:
- The field shows a strong annual growth rate of 37.49%.
- The USA and China are the top contributing countries.
- "Cancers" and "Oncotarget" are leading journals; "Pantziarka P" and "Bouche G" are prominent authors.
- Antineoplastic activity is a key research area, with pantoprazole and transwell assays as trending topics.
Conclusions:
- Drug repurposing in cancer research is a dynamic and growing field.
- Future research should explore antineoplastic agents, transwell assays, and candidate drugs like pantoprazole.
- This study offers valuable guidance for researchers in cancer drug repurposing.
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