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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Primary empty sella

Natalia Soledad Leon1, Soledad Sosa1, Nicolas Coronel-Restrepo2

  • 1Hospital de Clínicas José de San Martín.

Revista De La Facultad De Ciencias Medicas (Cordoba, Argentina)
|October 1, 2025
PubMed
Summary
This summary is machine-generated.

Primary empty sella (PES) often affects multiparous, obese, and hypertensive women. Comprehensive biochemical evaluation is crucial for detecting pituitary deficits and initiating timely treatment.

Keywords:
empty sella syndromepituitary diseaseshypopituitarism

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Area of Science:

  • Neuroendocrinology
  • Radiology
  • Internal Medicine

Background:

  • Primary empty sella (PES) involves herniation of the subarachnoid space into the sella turcica.
  • Diagnosis is frequently incidental, but symptomatic presentations occur.

Purpose of the Study:

  • To describe the clinical and demographic characteristics of patients diagnosed with Primary Empty Sella.
  • To identify common symptoms and pituitary dysfunctions in PES patients.

Main Methods:

  • Retrospective analysis of 63 patients diagnosed with PES between 1997-2021 from six specialized centers.
  • Diagnosis confirmed via MRI, pituitary functional evaluation, and neuro-ophthalmological assessment.

Main Results:

  • The study included 63 patients (79% female, mean age 52.3 years) with a high prevalence of obesity (68%) and hypertension (59%).
  • Most symptomatic patients (78%) presented with headache, endocrine dysfunction, or visual disturbances; 46% had hypopituitarism.
  • Partial PES was observed in 63% of cases.

Conclusions:

  • Contrary to incidental findings, most PES patients in this series were symptomatic.
  • Multiparous women, particularly those who are obese and hypertensive, represent a significant demographic.
  • Biochemical assessment is essential for identifying and managing pituitary deficits in PES patients.