Related Experiment Video
Updated: Jan 16, 2026
Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
Targeted Nanoactuator-Integrated Multicomponent Supramolecular Assemblies for Augmented Chemo/Chemodynamic
Shuai Chen1, Ning Han2, Yuheng Ren1
1Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, P. R. China.
Abstract:
Lung cancer remains the leading cause of cancer mortality, highlighting the need for innovative therapies. Aloe-emodin (AE), a natural anthraquinone from Aloe vera, faces clinical challenges due to tumor heterogeneity and immunosuppressive microenvironments. To address this, we combine chemodynamic therapy (CDT) with a novel supramolecular assembly (MIL-101(Fe)-Fc@AE@FACD), designed by functionalizing iron-based metal-organic frameworks (MIL-101(Fe)) with folic acid-conjugated cyclodextrin (FACD) for tumor targeting. This assembly enables dual therapeutic mechanisms: CDT-induced reactive oxygen species (ROS) generation and pH-triggered AE release. In vitro, it shows enhanced cytotoxicity against A549 cells, reducing cell viability to <15%. In vivo, it significantly inhibits tumor growth with minimal hepatorenal toxicity. This hybrid supramolecular platform enhances the antitumor efficacy of AE against lung cancer.
