Targeted Nanoactuator-Integrated Multicomponent Supramolecular Assemblies for Augmented Chemo/Chemodynamic...

Area of Science:

• Biomedical Engineering
• Materials Science
• Oncology

Background:

• Lung cancer is a leading cause of cancer mortality, necessitating novel therapeutic strategies.
• Aloe-emodin (AE) shows promise but faces challenges like tumor heterogeneity and immunosuppression.
• Current therapies require improvement to overcome treatment resistance and enhance efficacy.

Purpose of the Study:

• To develop a hybrid supramolecular platform for enhanced lung cancer treatment.
• To combine chemodynamic therapy (CDT) with aloe-emodin (AE) for synergistic effects.
• To improve tumor targeting and drug delivery for AE in lung cancer.

Main Methods:

• Fabrication of a supramolecular assembly (MIL-101(Fe)-Fc@AE@FACD) using iron-based metal-organic frameworks (MIL-101(Fe)) functionalized with folic acid-conjugated cyclodextrin (FACD).
• Integration of AE into the supramolecular structure for pH-triggered release.
• Evaluation of the platform's in vitro cytotoxicity against A549 lung cancer cells and in vivo antitumor efficacy and toxicity in a mouse model.

Main Results:

• The supramolecular assembly demonstrated potent chemodynamic therapy (CDT) by generating reactive oxygen species (ROS).
• In vitro studies showed enhanced cytotoxicity, reducing A549 cell viability to below 15%.
• In vivo experiments revealed significant inhibition of tumor growth with minimal observed hepatorenal toxicity.

Conclusions:

• The developed hybrid supramolecular platform effectively enhances the antitumor efficacy of aloe-emodin (AE) against lung cancer.
• This novel approach offers a promising strategy for overcoming challenges in AE-based cancer therapy.
• The combination of CDT and targeted delivery presents a viable therapeutic avenue for lung cancer treatment.