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Updated: Jan 16, 2026
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Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
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Disrupted rhythms and dysfunction: A chronobiological perspective on polycystic ovary syndrome
Ishanka Singh1, Pawan Kumar Maurya1
1Department of Biochemistry, Central University of Haryana, Mahendergarh, Haryana 123031, India.
Pathology, Research and Practice
|October 1, 2025
Summary
Polycystic Ovary Syndrome (PCOS) involves disrupted biological timing, affecting hormones and metabolism. Chronomedicine, using strategies like melatonin and timed feeding, offers new treatment avenues for PCOS.
Area of Science:
- Endocrinology
- Chronobiology
- Metabolic Disorders
Background:
- Polycystic Ovary Syndrome (PCOS) is a complex endocrine-metabolic disorder.
- Emerging evidence links circadian rhythm disruption to PCOS pathogenesis.
Purpose of the Study:
- To review the intersection of circadian dysregulation and PCOS.
- To explore chronobiological factors in PCOS development and manifestation.
Main Methods:
- Literature review of chronobiology and PCOS research.
- Analysis of clock gene expression, melatonin dynamics, and neuroendocrine pathways.
Main Results:
- Disrupted biological timing, including altered clock genes (CLOCK, BMAL1, PER1) and melatonin, is implicated in PCOS.
- Circadian disruption affects ovulatory function, insulin resistance, and hyperandrogenism.
Conclusions:
- Chronomedicine offers novel therapeutic strategies for PCOS.
- Circadian-informed care represents a paradigm shift for PCOS management.
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