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Related Concept Videos

MicroRNAs01:22

MicroRNAs

3.8K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
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MicroRNA biomarkers in psoriasis.

Shikha Singh1, Medha Rajappa1

  • 1Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|October 1, 2025
PubMed
Summary

MicroRNAs (miRNAs) show promise as biomarkers for psoriasis, a chronic skin disease. Research explores their role in diagnosis, prognosis, and personalized treatment strategies for better patient outcomes.

Keywords:
BiomarkersImmune systemPsoriasisSkin diseaseTherapeuticsmicroRNAs

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Area of Science:

  • Immunodermatology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Psoriasis is a T-helper cell-driven chronic inflammatory autoimmune skin condition with significant global socioeconomic impact.
  • Current understanding of psoriasis etiology and pathophysiology is incomplete, and treatment recurrence is frequent despite advanced biologics.
  • Identifying reliable biomarkers for early diagnosis, prognosis, and predicting therapeutic response in psoriasis remains a critical unmet need.

Purpose of the Study:

  • To review and consolidate evidence on the diagnostic and prognostic potential of microRNAs (miRNAs) in psoriasis.
  • To explore the role of specific miRNAs in psoriasis pathogenesis, disease severity, treatment response, and comorbidities.
  • To highlight the potential of miRNA profiling integrated with omics technologies and machine learning for personalized psoriasis management.

Main Methods:

  • Comprehensive literature review of studies investigating microRNAs in psoriasis.
  • Analysis of specific miRNA roles (e.g., miR-21, miR-31, miR-146a) in psoriasis pathogenesis and clinical associations.
  • Exploration of integrating miRNA profiling with omics technologies and machine learning for predictive algorithm development.

Main Results:

  • MicroRNAs are implicated in key psoriasis pathways including immune regulation, keratinocyte proliferation, and apoptosis.
  • Specific miRNAs (miR-21, miR-31, miR-99a, miR-146a, miR-125b, miR-203, miR-138, miR-155) are associated with psoriasis pathogenesis, severity, and treatment response.
  • Integration of miRNA profiling with omics and machine learning offers a framework for predictive biomarker development.

Conclusions:

  • MicroRNAs hold significant potential as diagnostic and prognostic biomarkers for psoriasis.
  • miRNA signatures can guide personalized treatment strategies and monitor therapeutic efficacy in psoriasis management.
  • Further research on standardized miRNA assays and mechanistic roles is crucial for clinical translation.