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Updated: Jan 16, 2026

Therapy Interventions for Upper Limb Amputees Undergoing Selective Nerve Transfers
Published on: October 29, 2021
Functional Outcomes of Individuals Undergoing the Ewing Amputation
Lori Berger1, Sarah Kelly Welch2, Sarah Danforth2
1Division of Plastic Surgery, Brigham & Women's Hospital, Boston, MA.
The Ewing amputation (EA) significantly improved patient physical function and self-reported outcomes compared to their preoperative state. Postoperative EA patients outperformed transtibial amputees (TTAs) and matched able-bodied adults (ABAs) on key mobility tests.
Area of Science:
- Orthopedics
- Rehabilitation Medicine
- Biomedical Engineering
Background:
- Transtibial amputation (TTA) often follows failed limb salvage, impacting physical function.
- The Ewing amputation (EA) is a novel surgical technique for TTA.
- EA incorporates agonist-antagonist myoneural interfaces to potentially improve prosthetic integration.
Purpose of the Study:
- To evaluate the postoperative functional outcomes of the Ewing amputation (EA).
- To compare EA patient performance against their own preoperative status.
- To benchmark EA outcomes against transtibial amputees (TTAs) and able-bodied adults (ABAs).
Main Methods:
- An intervention cohort study was conducted at a tertiary/quaternary academic medical center.
- Twenty-two patients (aged 18-65) undergoing elective TTA due to failed limb salvage were included.
- Physical function tests and patient-reported outcome measures were assessed preoperatively and postoperatively (approx. 1-year follow-up).
Main Results:
- All 22 EA patients achieved prosthetic fitting.
- EA patients showed statistically significant improvements in most functional and patient-reported outcomes compared to their preoperative state (P<.01).
- EA patients demonstrated superior performance over TTAs and equivalent performance to ABAs on several key mobility tests (e.g., 10-meter walk, Timed Up and Go).
Conclusions:
- The Ewing amputation (EA) combined with rehabilitation enhances patient physical function.
- EA offers improved postoperative physical function compared to traditional TTAs.
- EA patients achieve functional levels comparable to able-bodied adults on specific measures.
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