Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.4K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drug Prescribing Patterns in Geriatric Patients With Type 2 Diabetes Mellitus at a Tertiary Care Teaching Hospital: A Cross-Sectional Study.

Cureus·2026
Same author

Comment on "Effect of intraoperative remimazolam infusion on postoperative sleep disturbance in elderly patients after gynecological laparoscopy: a randomized clinical trial".

Anaesthesia, critical care & pain medicine·2026
Same author

Natural Polyphenols Versus Standard Therapy: Effects on Neuroinflammation and Alpha-Synuclein Expression in a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Mouse Model of Parkinson's Disease.

Cureus·2026
Same author

Comparative Efficacy of Pioglitazone, Saroglitazar, and Silymarin on Biochemical and Histopathological Hepatic Outcomes in a Wistar Rat Model of Non-alcoholic Fatty Liver Disease and Their Correlation With Insulin Sensitivity.

Cureus·2026
Same author

Artificial Intelligence in Osteoarthritis Diagnosis and Treatment: Advancements, Challenges, and Future Prospects.

Hand surgery & rehabilitation·2026
Same author

Cancer stem cell marker ALDH1 and CD44 expression: Independent predictors of survival outcome in oral cancer patients.

National journal of maxillofacial surgery·2026

Related Experiment Video

Updated: Jan 16, 2026

Orthotopic Injection of Breast Cancer Cells into the Mammary Fat Pad of Mice to Study Tumor Growth.
07:52

Orthotopic Injection of Breast Cancer Cells into the Mammary Fat Pad of Mice to Study Tumor Growth.

Published on: February 8, 2015

80.9K

In vivo cancer modeling using mouse models.

Prafulla Chandra Tiwari1, Manju J Chaudhary2, Rishi Pal1

  • 1Department of Pharmacology & Therapeutics, King George's Medical University, Lucknow, UP, India.

Methods in Cell Biology
|October 1, 2025
PubMed
Summary

Mouse models are crucial for advancing cancer research and drug development. New technologies enhance their accuracy, ensuring their continued relevance in preclinical testing for improved patient outcomes.

Keywords:
CRISPR/Cas9Cancer researchMouse modelsPersonalized medicineTumor biologyXenograft

More Related Videos

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.2K
In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer
07:46

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

Published on: August 17, 2010

34.4K

Related Experiment Videos

Last Updated: Jan 16, 2026

Orthotopic Injection of Breast Cancer Cells into the Mammary Fat Pad of Mice to Study Tumor Growth.
07:52

Orthotopic Injection of Breast Cancer Cells into the Mammary Fat Pad of Mice to Study Tumor Growth.

Published on: February 8, 2015

80.9K
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.2K
In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer
07:46

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

Published on: August 17, 2010

34.4K

Area of Science:

  • Oncology and Preclinical Research
  • Animal Models in Cancer Studies
  • Translational Cancer Research

Background:

  • Mouse models are indispensable tools in understanding cancer biology and developing novel therapeutic strategies.
  • Various mouse models, including xenograft, syngeneic, and humanized types, are utilized in cancer research.
  • Genetic engineering techniques are pivotal in generating these sophisticated preclinical models.

Purpose of the Study:

  • To provide a comprehensive overview of diverse mouse models used in cancer research.
  • To detail methodologies for tumor induction, engraftment, and their application in drug development and immuno-oncology.
  • To discuss ethical and regulatory aspects of animal use in research, particularly in India.

Main Methods:

  • Elaboration on xenograft, syngeneic, and humanized mouse models.
  • Description of genetic engineering techniques for model generation.
  • Review of tumor induction, engraftment procedures, and drug efficacy testing methodologies.

Main Results:

  • Mouse models remain highly relevant for studying tumor biology, microenvironment, and molecular pathways in preclinical settings.
  • Emerging technologies like CRISPR/Cas9 and organoid integration enhance model accuracy and translational potential.
  • Collaborative and open science initiatives promise advancements in in vivo cancer modeling.

Conclusions:

  • Mouse models are essential for advancing cancer research and personalized medicine, integrating classical and modern approaches.
  • The continued development and application of mouse models are critical for improving patient outcomes.
  • Future cancer modeling will benefit from technological integration and collaborative research efforts.